Rbl1 Gene Summary [Mouse]
Enables promoter-specific chromatin binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and retina. Used to study retinoblastoma and urinary bladder cancer. Orthologous to human RBL1 (RB transcriptional corepressor like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rbl1 |
| Official Name | RB transcriptional corepressor like 1 [Source:MGI Symbol;Acc:MGI:103300] |
| Ensembl ID | ENSMUSG00000027641 |
| Bio databases IDs | |
| Aliases | RB transcriptional corepressor like 1 |
| Synonyms | CP107, LOC683869, p107, p130, PRB1, RB transcriptional corepressor like 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rbl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C pocket domain
- transcription regulator
- Cyclin box fold superfamily
- chromatin binding
- cyclin recognition motif
- Domain of unknown function (DUF3452)
- domain present in cyclins, TFIIB and Retinoblastoma
- protein binding
- LXCXE binding site
- cyclin-CDK binding domain
- pocket domain
- cysteine-specific adenylation domain
- E2F protein-binding domain
- B domain
- spacer domain
- Retinoblastoma-associated protein B domain
- Retinoblastoma-associated protein A domain
- cyclin-binding domain
Pathways
Biological processes and signaling networks where the Rbl1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Aryl Hydrocarbon Receptor Signaling
- Bladder Cancer Signaling
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- DNA Methylation and Transcriptional Repression Signaling
- Estrogen-mediated S-phase Entry
- Glioma Signaling
- HER-2 Signaling in Breast Cancer
- Molecular Mechanisms of Cancer
- Non-Small Cell Lung Cancer Signaling
- Ovarian Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Role of BRCA1 in DNA Damage Response
- Role of Tissue Factor in Cancer
- Serotonin Receptor Signaling
- Small Cell Lung Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atresia
- head and neck neuroendocrine neoplasia
- head and neck neoplasia
- epithelial cancer
- growth failure
- tumorigenesis
- metastasis
- aortic valve calcification
- MYC mutation positive B-cell lymphoma
- lymphomagenesis
role in cell
- phosphorylation in
- expression in
- proliferation
- activation in
- binding in
- response
- apoptosis
- growth
- transactivation in
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rbl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression
- regulation of lipid kinase activity
- cell differentiation
- negative regulation of G1/S transition of mitotic cell cycle
- chromatin organization
- negative regulation of cellular senescence
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II regulatory region sequence-specific DNA binding