Trex2 Gene Summary [Mouse]
Predicted to enable several functions, including 3'-5'-DNA exonuclease activity; magnesium ion binding activity; and protein homodimerization activity. Predicted to be involved in DNA catabolic process. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human TREX2 (three prime repair exonuclease 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trex2 |
| Official Name | three prime repair exonuclease 2 [Source:MGI Symbol;Acc:MGI:1346343] |
| Ensembl ID | ENSMUSG00000031372 |
| Bio databases IDs | |
| Aliases | three prime repair exonuclease 2 |
| Synonyms | RGD1562245, three prime repair exonuclease 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trex2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
- exonuclease
- EXOIII
- protein homodimerization
- enzyme
- protein binding
- magnesium ion binding
- 3'-5' exodeoxyribonuclease
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trex2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA catabolic process
- DNA metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- DNA binding
- protein binding
- protein homodimerization activity
- 3'-5'-exodeoxyribonuclease activity
- double-stranded DNA specific 3'-5' exodeoxyribonuclease activity
- binding, bridging