Fmnl2 Gene Summary [Mouse]
Predicted to enable actin filament binding activity. Predicted to be involved in cell migration; cortical actin cytoskeleton organization; and regulation of cell shape. Predicted to be located in glutamatergic synapse and postsynapse. Predicted to be active in cytosol. Is expressed in brain. Orthologous to human FMNL2 (formin like 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fmnl2 |
| Official Name | formin-like 2 [Source:MGI Symbol;Acc:MGI:1918659] |
| Ensembl ID | ENSMUSG00000036053 |
| Bio databases IDs | |
| Aliases | formin-like 2 |
| Synonyms | 5430425K04RIK, FHOD2, formin-like 2, Man, RGD1560248 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fmnl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Formin Homology 2 Domain
- Diaphanous FH3 Domain
- Uncharacterized protein conserved in bacteria (DUF2312)
- Rho-binding domain
- formin homology domain 3
- Diaphanous GTPase-binding Domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- glaucoma
- asthma
- open-angle glaucoma
- Barrett syndrome
- pervasive developmental disorder
- astigmatism
- corneal astigmatism
- Moyamoya disease
regulates
- fascin
- actin
role in cell
- migration
- morphogenesis
- organization
- frequency
- formation in
- myofibrillogenesis in
- polymerization in
- assembly in
- repair
- ultrastructure
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- glutaminergic synapse
- postsynaptic region
- sarcomere
- cytosol
- anchoring junction
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fmnl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cortical actin cytoskeleton organization
- regulation of cell shape
- cytoskeleton organization
- regulation of cell morphogenesis
- cell migration
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- cadherin binding
- small GTPase binding