Aida Gene Summary [Mouse]
Enables protein domain specific binding activity. Involved in negative regulation of JNK cascade and negative regulation of protein-containing complex assembly. Acts upstream of or within negative regulation of JUN kinase activity and regulation of protein-containing complex assembly. Located in cytoplasm. Orthologous to human AIDA (axin interactor, dorsalization associated). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Aida |
| Official Name | axin interactor, dorsalization associated [Source:MGI Symbol;Acc:MGI:1919737] |
| Ensembl ID | ENSMUSG00000042901 |
| Bio databases IDs | |
| Aliases | axin interactor, dorsalization associated |
| Synonyms | 2610208M17Rik, axin interactor, dorsalization associated, C1orf80, FLJ12806 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aida often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Axin interactor dorsalization-associated protein, C-terminal
- protein domain specific binding
- protein binding
- Aida N-terminus
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- obesity
- hypothermia
- breast cancer
- insulin resistance
- hyperglycemia
- coronary artery disease
- ophthalmic disorder
role in cell
- binding in
- function
- size
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aida gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- determination of ventral identity
- negative regulation of JUN kinase activity
- negative regulation of protein complex assembly
- negative regulation of JNK cascade
- dorsal/ventral pattern formation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- phosphatidylinositol binding