Herpud1 Gene Summary [Mouse]
Enables ubiquitin-like ligase-substrate adaptor activity. Involved in protein targeting to ER; regulation of ERAD pathway; and regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Acts upstream of or within endoplasmic reticulum unfolded protein response; regulation of protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum membrane and endoplasmic reticulum quality control compartment. Is expressed in several structures, including clavicle; craniocervical region bone; early conceptus; and olfactory epithelium. Orthologous to human HERPUD1 (homocysteine inducible ER protein with ubiquitin like domain 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Herpud1 |
| Official Name | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 [Source:MGI Symbol;Acc:MGI:1927406] |
| Ensembl ID | ENSMUSG00000031770 |
| Bio databases IDs | |
| Aliases | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 |
| Synonyms | HERP, HERPUD, homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1, homocysteine inducible ER protein with ubiquitin like domain 1, Mif1, Mifl, SUP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Herpud1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin family
- Caspase 3 cleavage site
- Ubl1_cv_Nsp3_N-like
- protein binding activity, bridging
- ion channel binding
- Ubiquitin homologues
- protein binding
- ubiquitin-like domain
Pathways
Biological processes and signaling networks where the Herpud1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- metabolic syndrome X
- prostate cancer
- acute myocardial infarction
- Huntington disease
- hereditary breast and/or ovarian cancer
- prostatic carcinoma
role in cell
- replication in
- expression in
- apoptosis
- survival
- cell death
- degradation in
- transmembrane potential
- phosphorylation in
- endoplasmic reticulum stress response
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- microsome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Herpud1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- endoplasmic reticulum unfolded protein response
- protein targeting to ER
- retrograde protein transport, ER to cytosol
- regulation of protein ubiquitination
- endoplasmic reticulum calcium ion homeostasis
- negative regulation of intrinsic apoptotic signaling pathway
- response to unfolded protein
- response to endoplasmic reticulum stress
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum quality control compartment
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- ion channel binding