Ciapin1 Gene Summary [Mouse]
Predicted to enable 2 iron, 2 sulfur cluster binding activity and iron ion binding activity. Acts upstream of or within hemopoiesis and negative regulation of apoptotic process. Located in cytoplasm and nucleolus. Is expressed in several structures, including ganglia; sensory organ; submandibular gland primordium; tooth; and urinary system. Orthologous to human CIAPIN1 (cytokine induced apoptosis inhibitor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ciapin1 |
| Official Name | cytokine induced apoptosis inhibitor 1 [Source:MGI Symbol;Acc:MGI:1922083] |
| Ensembl ID | ENSMUSG00000031781 |
| Bio databases IDs | |
| Aliases | cytokine induced apoptosis inhibitor 1 |
| Synonyms | 2810413N20Rik, Anamorsin, CIAE2, cytokine induced apoptosis inhibitor 1, DRE2, PRO0915 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ciapin1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
- binding protein
- iron ion binding
- protein binding
- AdoMet_MTases
- methyltransferase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- invasive breast cancer
- organismal death
role in cell
- expression in
- phosphorylation in
- apoptosis
- number
- cell viability
- activation in
- molecular cleavage in
- abnormal morphology
- hematopoiesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ciapin1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of apoptotic process
- hemopoiesis
- apoptotic process
- iron-sulfur cluster assembly
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- cytoplasm
- mitochondrion
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- iron ion binding
- electron carrier activity
- 4 iron, 4 sulfur cluster binding
- 2 iron, 2 sulfur cluster binding