S100a6 Gene Summary [Mouse]
Enables calcium ion binding activity and zinc ion binding activity. Predicted to be involved in monoatomic ion transmembrane transport. Located in collagen-containing extracellular matrix. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and trophectoderm. Orthologous to human S100A6 (S100 calcium binding protein A6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | S100a6 |
| Official Name | S100 calcium binding protein A6 (calcyclin) [Source:MGI Symbol;Acc:MGI:1339467] |
| Ensembl ID | ENSMUSG00000001025 |
| Bio databases IDs | |
| Aliases | S100 calcium binding protein A6 (calcyclin) |
| Synonyms | 2A9, 5B10, CABP, CACY, CALCYCLIN, PRA, S100 calcium binding protein A6, S100 calcium binding protein A6 (calcyclin), S10A6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse S100a6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- EF-hand, calcium binding motif
- S-100/ICaBP type calcium binding domain
- zinc ion binding
- ion transporter
- tropomyosin binding
- calcium ion binding
- protein homodimerization
- EFh
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine leiomyoma
- lung cancer
- organismal death
- dermatomyositis
- systemic lupus erythematosus
- pancreatic cancer
- schizophrenia
- renal cell carcinoma
- renal cell cancer
- lung adenocarcinoma
role in cell
- apoptosis
- proliferation
- phosphorylation in
- migration
- production in
- growth
- survival
- invasion
- hypertrophy
- cell focus formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- ruffle
- Extracellular Space
- perinuclear region
- Nucleus
- Plasma Membrane
- cytosol
- cytoplasmic face of plasma membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse S100a6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- positive regulation of fibroblast proliferation
- axonogenesis
- ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nucleus
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- cytoplasm
- ruffle
- cytosol
- extracellular region
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein homodimerization activity
- protein binding
- calcium ion binding
- ion transmembrane transporter activity
- calcium-dependent protein binding
- tropomyosin binding
- S100 protein binding