Phpt1 Gene Summary [Mouse]
Predicted to enable several functions, including calcium channel inhibitor activity; protein histidine phosphatase activity; and transmembrane transporter binding activity. Involved in positive regulation of cell motility. Located in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Orthologous to human PHPT1 (phosphohistidine phosphatase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phpt1 |
| Official Name | phosphohistidine phosphatase 1 [Source:MGI Symbol;Acc:MGI:1922704] |
| Ensembl ID | ENSMUSG00000036504 |
| Bio databases IDs | |
| Aliases | phosphohistidine phosphatase 1 |
| Synonyms | 1700008C22Rik, CGI-202, HEL-S-132P, HSPC141, phosphohistidine phosphatase 1, PHP, PHP14, SRP JANUS-A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Phpt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Janus/Ocnus family (Ocnus)
- calcium channel inhibitor
- protein phosphatase
- enzyme inhibitor activity
- phosphatase
- ion channel binding
- phosphorus-nitrogen bond hydrolase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
- nuclear bodies
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Phpt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-histidine dephosphorylation
- negative regulation of T cell receptor signaling pathway
- negative regulation of lyase activity
- protein dephosphorylation
- negative regulation of ATP citrate synthase activity
- actin cytoskeleton organization
- positive regulation of cell motility
Cellular Component
Where in the cell the gene product is active
- nuclear body
- extracellular vesicular exosome
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- ion channel binding
- calcium channel inhibitor activity