Hsbp1 Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Acts upstream of or within endodermal cell differentiation. Predicted to be located in axon cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including early embryo and ganglia. Orthologous to human HSBP1 (heat shock factor binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hsbp1 |
| Official Name | heat shock factor binding protein 1 [Source:MGI Symbol;Acc:MGI:1915446] |
| Ensembl ID | ENSMUSG00000031839 |
| Bio databases IDs | |
| Aliases | heat shock factor binding protein 1 |
| Synonyms | 0610007A03Rik, heat shock factor binding protein 1, Hsf, HSF1BP, Hsp25, NPC-A-13 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hsbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Heat shock factor binding protein 1
- RXXs motif
- transcription co-repressor
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- periodontitis
role in cell
- differentiation
- migration
- number
- invasion by
- polarization
- axonal transport
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hsbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- cellular heat acclimation
- endodermal cell differentiation
- axon transport of mitochondrion
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- transcription corepressor activity