Sprtn Gene Summary [Mouse]
Predicted to enable several functions, including DNA binding activity; K63-linked polyubiquitin modification-dependent protein binding activity; and metalloendopeptidase activity. Involved in protein-DNA covalent cross-linking repair. Predicted to be located in chromatin and nuclear speck. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Ruijs-Aalfs syndrome. Orthologous to human SPRTN (SprT-like N-terminal domain). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sprtn |
| Official Name | SprT-like N-terminal domain [Source:MGI Symbol;Acc:MGI:2685351] |
| Ensembl ID | ENSMUSG00000031986 |
| Bio databases IDs | |
| Aliases | SprT-like N-terminal domain |
| Synonyms | C1orf124, DVC1, Gm505, PRO4323, RGD1559496, Spartan, SprT-like N-terminal domain |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sprtn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SprT-like family
- YgjP-like, metallopeptidase domain
- single-stranded DNA binding
- Rad18-like CCHC zinc finger
- double-stranded DNA binding
- peptidase
- ubiquitin binding
- protein binding
- SprT homologues
- metalloendopeptidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sprtn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- positive regulation of protein ubiquitination
- response to UV
- protein autoprocessing
- response to DNA damage stimulus
- translesion synthesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin binding
- polyubiquitin binding
- metal ion binding
- K63-linked polyubiquitin binding
- double-stranded DNA binding
- metalloendopeptidase activity
- single-stranded DNA binding