Top3a Gene Summary [Mouse]
Predicted to enable DNA topoisomerase type I (single strand cut, ATP-independent) activity and single-stranded DNA binding activity. Predicted to be involved in DNA metabolic process and chromosome separation. Predicted to be located in PML body. Predicted to be part of RecQ family helicase-topoisomerase III complex. Predicted to be active in nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5. Orthologous to human TOP3A (DNA topoisomerase III alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Top3a |
| Official Name | topoisomerase (DNA) III alpha [Source:MGI Symbol;Acc:MGI:1197527] |
| Ensembl ID | ENSMUSG00000002814 |
| Bio databases IDs | |
| Aliases | topoisomerase (DNA) III alpha |
| Synonyms | DNA topoisomerase III alpha, DNA topoisomerase III α, MGRISCE2, PEOB5, TOP3, Top3 alpha, Top3 α, topoisomerase (DNA) III alpha, topoisomerase (DNA) III α, ZGRF7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Top3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA topoisomerase type I
- Bacterial DNA topoisomeraes I ATP-binding domain
- Topoisomerase DNA binding C4 zinc finger
- DNA topoisomerase I, archaeal
- TOPRIM
- Toprim domain
- topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins
- GRF zinc finger
- enzyme
- protein binding
- DNA binding
- Bacterial DNA topoisomerase I DNA-binding domain
- DNA topoisomerase
- single-stranded DNA binding
- TOP1Ac
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- hereditary disorder
- uterine leiomyoma
- leiomyomatosis
- microcephaly, growth restriction and increased sister chromatid exchange-2
- mitochondrial disorder
- autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions type 5
role in cell
- expression in
- survival
- growth
- colony formation
- cell viability
- recombination
- formation
- maintenance
- formation in
- maintenance in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
- cytosol
- mitochondrial matrix
- nuclear foci
- chromosome
- nucleoplasm
- nuclear bodies
- PML nuclear bodies
- chromosomal axial elements
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Top3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- meiotic cell cycle
- mitochondrial DNA metabolic process
- DNA recombination
- double-strand break repair via homologous recombination
- resolution of recombination intermediates
- DNA topological change
- chromosome separation
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
- mitochondrial matrix
- RecQ helicase-Topo III complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding
- DNA topoisomerase type I activity
- single-stranded DNA binding