Rpl10 Gene Summary [Mouse]
A structural constituent of ribosome. Predicted to be involved in several processes, including embryonic brain development; regulation of gene expression; and translation. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in synapse. Colocalizes with smooth endoplasmic reticulum. Is expressed in several structures, including limb; nervous system; otocyst; skin; and surface ectoderm. Human ortholog(s) of this gene implicated in autistic disorder and syndromic X-linked mental retardation 35. Orthologous to human RPL10 (ribosomal protein L10). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rpl10 |
| Official Name | ribosomal protein L10 [Source:MGI Symbol;Acc:MGI:105943] |
| Ensembl ID | ENSMUSG00000008682 |
| Bio databases IDs | |
| Aliases | ribosomal protein L10 |
| Synonyms | AUTSX5, D0HXS648, DXHXS648, DXHXS648E, DXS648, DXS648E, JIF1, L10, MRXS35, NOV, QM, QM16, Ribosomal protein 10, ribosomal protein L10, Tumor suppressor QM, tumour suppressor QM, uL16 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rpl10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of ribosome
- Ribosomal_L16_L10e
- Ribosomal protein L16p/L10e
- protein binding
- zinc finger domain
- translation regulator
Pathways
Biological processes and signaling networks where the Rpl10 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- T acute lymphoblastic leukemia
- syndromic X-linked mental retardation type 35
- COVID-19
- syndromic X-linked mental retardation
- susceptibility to X-linked autism type 5
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
role in cell
- apoptosis
- proliferation
- cell death
- transactivation in
- necroptosis
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- cellular membrane
- ribosome
- Nucleus
- Endoplasmic Reticulum
- cytosol
- synapse
- smooth endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rpl10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of translation
- negative regulation of apoptotic process
- cytoplasmic translation
- ribosomal large subunit assembly
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosolic ribosome
- smooth endoplasmic reticulum
- membrane
- cytosol
- endoplasmic reticulum
- macromolecular complex
- cytosolic large ribosomal subunit
Molecular Function
What the gene product does at the molecular level
- translation regulator activity
- protein binding
- RNA binding
- structural constituent of ribosome