Dcun1d5 Gene Summary [Mouse]

Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Predicted to be involved in several processes, including positive regulation of protein neddylation; protein neddylation; and regulation of cell growth. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; jaw; nervous system; and thymus primordium. Orthologous to human DCUN1D5 (defective in cullin neddylation 1 domain containing 5). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Dcun1d5
Official Name
DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1924113]
Ensembl ID
ENSMUSG00000032002
Bio databases IDs NCBI: 76863 Ensembl: ENSMUSG00000032002
Aliases DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)
Synonyms 3110001A18Rik, 4833420K19RIK, AW060460, D430047L21Rik, DCNL5, defective in cullin neddylation 1 domain containing 5, Hs.167721, RGD1307008, SCCRO5
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dcun1d5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • PONY domain
  • nuclear localization sequence
  • protein binding
  • Cullin binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • tuberculosis
  • organismal death
  • preeclampsia
  • cardiovascular disorder
  • neoplastic cell transformation
regulates
role in cell
  • growth
  • cell viability
  • DNA damage response

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • spindle apparatus

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Dcun1d5 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • regulation of cell growth
  • protein neddylation
  • positive regulation of protein neddylation
  • response to DNA damage stimulus
  • regulation of protein neddylation

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • ubiquitin ligase complex
  • cytoplasm
  • spindle

Molecular Function

What the gene product does at the molecular level
  • small conjugating protein binding
  • ubiquitin conjugating enzyme binding
  • protein binding

Gene-Specific Assays for Results You Can Trust

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