Ppp2r1b Gene Summary [Mouse]
Predicted to enable protein phosphatase regulator activity. Predicted to be involved in several processes, including meiotic sister chromatid cohesion, centromeric; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; and spindle assembly. Is active in glutamatergic synapse. Is expressed in several structures, including cerebral cortex; eye; genitourinary system; thymus primordium; and tooth. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human PPP2R1B (protein phosphatase 2 scaffold subunit Abeta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ppp2r1b |
| Official Name | protein phosphatase 2, regulatory subunit A, beta [Source:MGI Symbol;Acc:MGI:1920949] |
| Ensembl ID | ENSMUSG00000032058 |
| Bio databases IDs | |
| Aliases | protein phosphatase 2, regulatory subunit A, beta |
| Synonyms | 2410091N08RIK, LOC101928690, PP2A-Abeta, Pp2a-a β, PR65B, protein phosphatase 2, regulatory subunit A, beta, protein phosphatase 2, regulatory subunit A, β, protein phosphatase 2 scaffold subunit A beta, protein phosphatase 2 scaffold subunit A β |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppp2r1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HEAT repeat
- HEAT-like repeat
- phosphoprotein phosphatase
- phosphatase
- protein binding
- HEAT repeats
Pathways
Biological processes and signaling networks where the Ppp2r1b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- ATM Signaling
- Autophagy
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cell Cycle Regulation by BTG Family Proteins
- Ceramide Signaling
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Cyclins and Cell Cycle Regulation
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- ERK/MAPK Signaling
- HIPPO signaling
- ILK Signaling
- Mitotic Roles of Polo-Like Kinase
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of eIF4 and p70S6K Signaling
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Telomerase Signaling
- Tight Junction Signaling
- WNT/β-catenin Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- coronary artery disease
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- epithelial neoplasia
- cancer
- androgenic alopecia
- colon cancer
- lung cancer
- breast carcinoma
role in cell
- cell death
- apoptosis
- survival
- growth
- phosphorylation in
- meiosis
- transformation
- meiotic recombination in
- dephosphorylation in
- inactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Nucleus
- synapse
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppp2r1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process involved in morphogenesis
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
- protein dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- membrane raft
- cytosol
- protein phosphatase type 2A complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein phosphatase regulator activity