Bcl2l10 Gene Summary [Mouse]
Enables identical protein binding activity. Involved in microtubule organizing center organization. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of intrinsic apoptotic signaling pathway; and positive regulation of apoptotic process. Located in membrane and spindle. Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system; liver; and meninges. Human ortholog(s) of this gene implicated in multiple myeloma; myelodysplastic syndrome; and stomach carcinoma. Orthologous to human BCL2L10 (BCL2 like 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bcl2l10 |
| Official Name | Bcl2-like 10 [Source:MGI Symbol;Acc:MGI:1330841] |
| Ensembl ID | ENSMUSG00000032191 |
| Bio databases IDs | |
| Aliases | Bcl2-like 10 |
| Synonyms | BCL2 like 10, BCL-B, Boo, Diva |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bcl2l10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bcl-2_like
- apoptosis regulator
- protease binding
- Bcl-2 homology 1 domain
- Bcl-2 homology 2 domain
- Bcl-2 homology 3 domain
- transmembrane domain
- calcium ion binding
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Bcl2l10 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- diffuse large B-cell lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- leukemogenesis
role in cell
- apoptosis
- cell death
- number
- survival
- quantity
- organization
- processing in
- generation
- binding in
- stabilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- endoplasmic reticulum mitochondria contact site
- spindle apparatus
- cellular membrane
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- mitochondrial outer membrane
- perinuclear space
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bcl2l10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- female gamete generation
- negative regulation of apoptotic process
- spermatogenesis
- apoptotic process
- release of cytochrome c from mitochondria
- DNA damage response, signal transduction resulting in induction of apoptosis
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- extrinsic apoptotic signaling pathway in absence of ligand
- microtubule organizing center organization
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- mitochondrion
- membrane
- spindle
- cytosol
- ER-mitochondrion membrane contact site
- endoplasmic reticulum
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- BH domain binding
- protein binding
- calcium ion binding