Klhdc2 Gene Summary [Mouse]
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to be located in nuclear body and nuclear membrane. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human KLHDC2 (kelch domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Klhdc2 |
| Official Name | kelch domain containing 2 [Source:MGI Symbol;Acc:MGI:1916804] |
| Ensembl ID | ENSMUSG00000020978 |
| Bio databases IDs | |
| Aliases | kelch domain containing 2 |
| Synonyms | 2310022K15Rik, D12Ertd522e, HCLP-1, kelch domain containing 2, LCP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klhdc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- protein binding activity, bridging
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- nucleoplasm
- nuclear bodies
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klhdc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- nuclear body
- Cul2-RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding