Fem1b Gene Summary [Rat]
Predicted to enable death receptor binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in regulation of signal transduction; regulation of ubiquitin-protein transferase activity; and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to act upstream of or within branching involved in prostate gland morphogenesis; epithelial cell maturation involved in prostate gland development; and protein ubiquitination. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human FEM1B (fem-1 homolog B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fem1b |
| Official Name | fem-1 homolog B [Source:RGD Symbol;Acc:1304569] |
| Ensembl ID | ENSRNOG00000007077 |
| Bio databases IDs | |
| Aliases | fem-1 homolog B |
| Synonyms | F1AA, F1A-ALPHA, F1A-α, FEM1-beta, fem-1 homolog B, FEM1-β, Feminization 1b homolog, mKIAA0396 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fem1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- death receptor binding
- transcription regulator
- Ankyrin repeats (many copies)
- protein binding activity, bridging
- Ankyrin repeats (3 copies)
- protein binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- idiopathic pulmonary fibrosis
- systemic juvenile idiopathic arthritis
role in cell
- phosphorylation in
- apoptosis
- maturation
- survival
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fem1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- branching involved in prostate gland morphogenesis
- proteasomal ubiquitin-dependent protein catabolic process
- apoptotic process
- regulation of DNA damage checkpoint
- regulation of ubiquitin-protein ligase activity
- epithelial cell maturation involved in prostate gland development
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- Cul2-RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- death receptor binding