Senp5 Gene Summary [Mouse]
Predicted to enable SUMO-specific endopeptidase activity and deSUMOylase activity. Predicted to be involved in protein desumoylation. Is active in postsynaptic cytosol and presynaptic cytosol. Is expressed in heart and nervous system. Orthologous to human SENP5 (SUMO specific peptidase 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Senp5 |
| Official Name | SUMO/sentrin specific peptidase 5 [Source:MGI Symbol;Acc:MGI:2443596] |
| Ensembl ID | ENSMUSG00000022772 |
| Bio databases IDs | |
| Aliases | SUMO/sentrin specific peptidase 5 |
| Synonyms | 6230429P13RIK, A730063F07RIK, BB189556, FKSG45, IMAGE 4386363, LOC686286, SMT3IP3, SUMO/sentrin specific peptidase 5, SUMO specific peptidase 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Senp5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine endopeptidase
- Ulp1 protease family, C-terminal catalytic domain
- peptidase
- DEK C terminal domain
- protein binding
- Sentrin-specific protease 3/5 N-terminal
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Senp5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- productive infection by HIV-1
role in cell
- expression in
- cell division
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Senp5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- protein sumoylation
- protein desumoylation
- proteolysis
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- SUMO-specific protease activity
- SUMO-specific endopeptidase activity