FEM1B Gene Summary [Human]
This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]
Details
| Type | Protein Coding |
| Official Symbol | FEM1B |
| Official Name | fem-1 homolog B [Source:HGNC Symbol;Acc:HGNC:3649] |
| Ensembl ID | ENSG00000169018 |
| Bio databases IDs | |
| Aliases | fem-1 homolog B |
| Synonyms | F1AA, F1A-ALPHA, F1A-α, FEM1-beta, fem-1 homolog B, FEM1-β, Feminization 1b homolog, mKIAA0396 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FEM1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- death receptor binding
- transcription regulator
- Ankyrin repeats (many copies)
- protein binding activity, bridging
- Ankyrin repeats (3 copies)
- protein binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- idiopathic pulmonary fibrosis
- systemic juvenile idiopathic arthritis
role in cell
- phosphorylation in
- apoptosis
- maturation
- survival
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FEM1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- branching involved in prostate gland morphogenesis
- proteasomal ubiquitin-dependent protein catabolic process
- apoptotic process
- regulation of DNA damage checkpoint
- regulation of ubiquitin-protein ligase activity
- epithelial cell maturation involved in prostate gland development
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- Cul2-RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- death receptor binding