Glce Gene Summary [Mouse]
Enables heparosan-N-sulfate-glucuronate 5-epimerase activity. Involved in heparan sulfate proteoglycan biosynthetic process and heparin proteoglycan biosynthetic process. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in cerebrovascular disease and hypertension. Orthologous to human GLCE (glucuronic acid epimerase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Glce |
| Official Name | glucuronyl C5-epimerase [Source:MGI Symbol;Acc:MGI:2136405] |
| Ensembl ID | ENSMUSG00000032252 |
| Bio databases IDs | |
| Aliases | glucuronyl C5-epimerase |
| Synonyms | 1110017N23RIK, C130034A12RIK, glucuronic acid epimerase, glucuronyl C5-epimerase, HSEPI, KIAA0836, MGI:2136405, RGD1565253, Riken 1110017N23 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Glce often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carbohydrate racemase or epimerase
- calcium ion binding
- UDPglucuronate 5'-epimerase
- protein homodimerization
- enzyme
- D-glucuronyl C5-epimerase C-terminus
- heparosan-N-sulfate-glucuronate 5-epimerase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cleft palate
- aortic valve calcification
- polydactyly
- congenital malformation
- agenesis
- respiratory failure
- iris coloboma
role in cell
- proliferation
- 6-O-sulfation in
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Glce gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heparan sulfate proteoglycan biosynthetic process
- positive regulation of cell proliferation
- positive regulation of SMAD protein import into nucleus
- heparin biosynthetic process
- negative regulation of cell projection organization
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- racemase and epimerase activity, acting on carbohydrates and derivatives
- calcium ion binding
- heparosan-N-sulfate-glucuronate 5-epimerase activity