Gpihbp1 Gene Summary [Mouse]
Enables lipase binding activity; lipoprotein particle binding activity; and protein transporter activity. Involved in several processes, including cholesterol homeostasis; positive regulation of chylomicron remnant clearance; and protein transport. Acts upstream of or within lipid transport. Located in apical plasma membrane; basolateral plasma membrane; and external side of plasma membrane. Is expressed in lung vascular element. Human ortholog(s) of this gene implicated in familial GPIHBP1 deficiency. Orthologous to human GPIHBP1 (glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpihbp1 |
| Official Name | GPI-anchored HDL-binding protein 1 [Source:MGI Symbol;Acc:MGI:1915703] |
| Ensembl ID | ENSMUSG00000022579 |
| Bio databases IDs | |
| Aliases | GPI-anchored HDL-binding protein 1 |
| Synonyms | 1110002J19Rik, glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1, GPI-anchored HDL-binding protein 1, HYPL1D, LOC338328, RGD1564237 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpihbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- enzyme binding
- high-density lipoprotein binding
- protein binding
- TFP
- enzyme activator activity
- acidic domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic pulmonary fibrosis
- hyperlipoproteinemia type 1D
- chylomicronemia
- preeclampsia
- lipoprotein lipase deficiency
role in cell
- binding in
- molecular cleavage in
- binding
- transcytosis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- plasma membrane extracellular face
- apical membrane
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpihbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization at cell surface
- transcytosis
- positive regulation of chylomicron remnant clearance
- triglyceride catabolic process
- protein stabilization
- intracellular protein transport
- triglyceride homeostasis
- cholesterol homeostasis
- protein import
- positive regulation of lipoprotein lipase activity
- response to heparin
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- extracellular region
- basolateral plasma membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- lipase binding
- protein binding
- lipoprotein lipase activator activity
- acetylcholine receptor inhibitor activity
- lipid binding
- lipoprotein particle binding
- chylomicron binding