Tent5a Gene Summary [Mouse]
Enables poly(A) RNA polymerase activity. Involved in positive regulation of bone mineralization and positive regulation of osteoblast differentiation. Acts upstream of or within response to bacterium. Located in cytoplasm. Is expressed in several structures, including heart; jaw; liver; oral epithelium; and skeleton. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; osteoarthritis; and osteogenesis imperfecta type 18. Orthologous to human TENT5A (terminal nucleotidyltransferase 5A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tent5a |
| Official Name | terminal nucleotidyltransferase 5A [Source:MGI Symbol;Acc:MGI:2670964] |
| Ensembl ID | ENSMUSG00000032265 |
| Bio databases IDs | |
| Aliases | terminal nucleotidyltransferase 5A |
| Synonyms | BAP014, C6orf37, D930050G01Rik, FAM46A, OI18, RGD1311381, terminal nucleotidyltransferase 5A, XTP11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tent5a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleotidyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- myocardial infarction
- breast carcinoma
- angina pectoris
- daytime sleepiness
- osteogenesis imperfecta type XVIII
- coronary artery disease
role in cell
- differentiation
- ossification by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tent5a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to bacterium
- mRNA stabilization
- positive regulation of osteoblast differentiation
- regulation of ossification
- positive regulation of bone mineralization
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding