Mto1 Gene Summary [Mouse]
Predicted to enable flavin adenine dinucleotide binding activity. Acts upstream of or within mitochondrial tRNA wobble uridine modification. Located in mitochondrion. Used to study combined oxidative phosphorylation deficiency. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 10. Orthologous to human MTO1 (mitochondrial tRNA translation optimization 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mto1 |
| Official Name | mitochondrial tRNA translation optimization 1 [Source:MGI Symbol;Acc:MGI:1915541] |
| Ensembl ID | ENSMUSG00000032342 |
| Bio databases IDs | |
| Aliases | mitochondrial tRNA translation optimization 1 |
| Synonyms | 2310039H01Rik, 5730419A02Rik, CGI-02, COXPD10, mitochondrial tRNA translation optimization 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mto1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glucose inhibited division protein A
- tRNA modifying enzyme MnmG/GidA C-terminal domain
- transferase
- enzyme
- glucose-inhibited division protein A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- bipolar disorder
- combined oxidative phosphorylation deficiency 10
- hereditary disorder
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- oxidative phosphorylation disease
- global developmental delay
- mitochondrial disorder
regulated by
- NUDT21
- tamoxifen
- trichostatin A
role in cell
- proliferation
- migration
- expression in
- apoptosis
- invasion by
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mto1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA methylation
- mitochondrial tRNA wobble uridine modification
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- RNA binding
- flavin adenine dinucleotide binding