Aspm Gene Summary [Mouse]
Enables calmodulin binding activity. Involved in regulation of meiotic cell cycle. Acts upstream of or within several processes, including maintenance of centrosome location; nervous system development; and neuronal stem cell population maintenance. Located in cytoplasm; microtubule cytoskeleton; and midbody. Is expressed in several structures, including gonad; gut; hemolymphoid system gland; nervous system; and perichondrium. Used to study microcephaly. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly and primary autosomal recessive microcephaly 5. Orthologous to human ASPM (assembly factor for spindle microtubules). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aspm |
| Official Name | abnormal spindle microtubule assembly [Source:MGI Symbol;Acc:MGI:1334448] |
| Ensembl ID | ENSMUSG00000033952 |
| Bio databases IDs | |
| Aliases | abnormal spindle microtubule assembly |
| Synonyms | abnormal spindle microtubule assembly, ASP, assembly factor for spindle microtubules, CALMBP1, D330028K02Rik, FLJ10517, FLJ10517 FIS, FLJ12505 FIS, MCPH5, Sha1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aspm often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transmembrane protein 131-like N-terminal
- IQ (isoleucine-glutamine) motif containing G and D (IQCG and IQCD)
- Calponin homology domain
- calmodulin binding
- calponin homology (CH) domain superfamily
- Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- epithelial cancer
- epithelial neoplasia
- non-small cell lung carcinoma
- diffuse large B-cell lymphoma
- autosomal recessive primary microcephaly type 5
- non-small cell lung cancer
- hepatocellular carcinoma
- gastric adenocarcinoma
role in cell
- number
- replication in
- phosphorylation in
- cell division
- quantity
- migration
- proliferation
- invasion by
- differentiation
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- microtubules
- midbody
- apical membrane
- spindle pole
- meiotic spindles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aspm gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spindle organization
- male gonad development
- spermatogenesis
- negative regulation of neuron differentiation
- positive regulation of canonical Wnt receptor signaling pathway
- positive regulation of neuroblast proliferation
- asymmetric cell division
- cerebral cortex development
- developmental growth
- negative regulation of asymmetric cell division
- neuronal stem cell maintenance
- forebrain neuroblast division
- spindle localization
- regulation of meiotic cell cycle
- neuron migration
- maintenance of centrosome location
- oogenesis
- spindle assembly involved in meiosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- meiotic spindle
- midbody
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- calmodulin binding