Hcn4 Gene Summary [Mouse]
Enables intracellularly cAMP-activated cation channel activity. Acts upstream of or within in utero embryonic development; monoatomic cation transport; and regulation of heart contraction. Located in axon. Is expressed in several structures, including eye; future brain; heart; septum transversum; and venous system. Human ortholog(s) of this gene implicated in Brugada syndrome 8; Gilles de la Tourette syndrome; generalized epilepsy; and sick sinus syndrome. Orthologous to human HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hcn4 |
| Official Name | hyperpolarization-activated, cyclic nucleotide-gated K+ 4 [Source:MGI Symbol;Acc:MGI:1298209] |
| Ensembl ID | ENSMUSG00000032338 |
| Bio databases IDs | |
| Aliases | hyperpolarization-activated, cyclic nucleotide-gated K+ 4 |
| Synonyms | Bcng3, BRGDA8, EIG18, Hcn3, hyperpolarization-activated, cyclic nucleotide-gated K+ 4, hyperpolarization activated cyclic nucleotide-gated potassium channel 4, SSS2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hcn4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- voltage-gated sodium channel
- Cyclic nucleotide-binding domain
- voltage-gated potassium channel
- Ion transport protein
- Ion transport protein N-terminal
- intracellular cAMP activated cation channel
- protein binding
- identical protein binding
- ion channel
- CAP_ED
- Cyclic nucleotide-monophosphate binding domain
Pathways
Biological processes and signaling networks where the Hcn4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- left ventricular noncompaction
- brugada syndrome type 8
- sick sinus syndrome 2 with cardiac noncompaction
- sick sinus syndrome type 2 with cardiac noncompaction and ascending aorta dilation
- susceptibility to idiopathic generalized epilepsy type 18
- autosomal dominant sick sinus syndrome type 2
- Brugada syndrome type 1
regulates
- K+
- cation
- Na+
role in cell
- transmembrane potential
- response by
- beating
- depolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular compartment
- intracellular space
- perinuclear region
- cellular membrane
- basolateral membrane
- perikaryon
- axons
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hcn4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane depolarization involved in regulation of SA node cardiac muscle cell action potential
- membrane depolarization involved in regulation of cardiac muscle cell action potential
- potassium ion transmembrane transport
- regulation of SA node cardiac muscle cell action potential
- blood circulation
- sinoatrial node development
- regulation of membrane depolarization
- regulation of heart rate
- cation transport
- regulation of membrane potential
- cellular response to cGMP
- muscle contraction
- cellular response to cAMP
- sodium ion transmembrane transport
- regulation of heart rate by cardiac conduction
- regulation of cardiac muscle contraction
Cellular Component
Where in the cell the gene product is active
- dendrite
- perinuclear region of cytoplasm
- plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- voltage-gated potassium channel activity
- identical protein binding
- protein binding
- cAMP binding
- intracellular cAMP activated cation channel activity
- voltage-gated sodium channel activity
- voltage-gated potassium channel activity involved in SA node cell action potential depolarization