Hcn2 Gene Summary [Mouse]
Predicted to enable several functions, including PDZ domain binding activity; identical protein binding activity; and monoatomic cation channel activity. Acts upstream of or within regulation of membrane potential. Located in membrane. Is expressed in central nervous system and heart. Human ortholog(s) of this gene implicated in familial febrile seizures 2. Orthologous to human HCN2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hcn2 |
| Official Name | hyperpolarization-activated, cyclic nucleotide-gated K+ 2 [Source:MGI Symbol;Acc:MGI:1298210] |
| Ensembl ID | ENSMUSG00000020331 |
| Bio databases IDs | |
| Aliases | hyperpolarization-activated, cyclic nucleotide-gated K+ 2 |
| Synonyms | BCNG-2, EIG17, FEB2, GEFSP11, HAC-1, hyperpolarization-activated, cyclic nucleotide-gated K+ 2, hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2, trls |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hcn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ion transport protein
- Ion transport protein N-terminal
- intracellular cAMP activated cation channel
- protein binding
- identical protein binding
- ion channel
- Cyclic nucleotide-monophosphate binding domain
- PDZ-domain binding
- voltage-gated sodium channel
- Cyclic nucleotide-binding domain
- voltage-gated potassium channel
- binding protein
- CAP_ED
Pathways
Biological processes and signaling networks where the Hcn2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- diabetic nephropathy
- prostate cancer
- susceptibility to idiopathic generalized epilepsy type 17
- autosomal recessive susceptibility to idiopathic generalized epilepsy type 17
- tremor
- familial febrile seizures type 2
- ataxia
- absence seizure
- adult T-cell leukemia/lymphoma
regulates
- CACNA1C
- Na+
- K+
- ammonium
role in cell
- quantity
- transmembrane potential
- response by
- action potential
- beating
- function
- afterhyperpolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- somatodendritic region
- cellular membrane
- synaptic vesicles
- perikaryon
- axons
- dendrites
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hcn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transmembrane transport
- regulation of membrane potential
- membrane depolarization involved in regulation of cardiac muscle cell action potential
- ammonium transmembrane transport
- cellular response to cGMP
- cellular response to cAMP
- cell-cell signaling
- sodium ion transmembrane transport
- regulation of membrane depolarization
Cellular Component
Where in the cell the gene product is active
- dendrite
- voltage-gated potassium channel complex
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- voltage-gated potassium channel activity
- identical protein binding
- protein binding
- intracellular cAMP activated cation channel activity
- cAMP binding
- voltage-gated sodium channel activity