Thbs3 Gene Summary [Mouse]
Predicted to enable heparin binding activity. Acts upstream of or within bone trabecula formation; growth plate cartilage development; and ossification involved in bone maturation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in collagen-containing extracellular matrix. Is expressed in several structures, including brain; lung; musculoskeletal system; sensory organ; and urinary system. Orthologous to human THBS3 (thrombospondin 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Thbs3 |
| Official Name | thrombospondin 3 [Source:MGI Symbol;Acc:MGI:98739] |
| Ensembl ID | ENSMUSG00000028047 |
| Bio databases IDs | |
| Aliases | thrombospondin 3 |
| Synonyms | LOC100503360, thrombospondin 3, TSP3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Thbs3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin C-terminal region
- Coiled coil region of thrombospondin
- LamG
- EGF domain
- protein binding
- heparin binding
- thrombospondin type 3 repeat
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- gastric carcinoma
- gastric epithelial cancer
- weight gain
- critical COVID-19
- osteosarcoma
- osteosarcomagenesis
- colorectal polyp
- idiopathic pulmonary fibrosis
- Huntington disease
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- perinuclear region
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Thbs3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- growth plate cartilage development
- bone trabecula formation
- ossification involved in bone maturation
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- heparin binding
- extracellular matrix structural constituent