Plod2 Gene Summary [Mouse]
Predicted to enable procollagen-lysine 5-dioxygenase activity. Predicted to be involved in collagen fibril organization; hydroxylysine biosynthetic process; and peptidyl-lysine hydroxylation. Predicted to be located in rough endoplasmic reticulum membrane. Predicted to be active in several cellular components, including Golgi apparatus; collagen-containing extracellular matrix; and endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; branchial arch; cranium; and sensory organ. Used to study Bruck syndrome. Orthologous to human PLOD2 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plod2 |
| Official Name | procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 [Source:MGI Symbol;Acc:MGI:1347007] |
| Ensembl ID | ENSMUSG00000032374 |
| Bio databases IDs | |
| Aliases | procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 |
| Synonyms | BRKS2, D530025C14Rik, LH2, Lysyl hydroxylase 2, procollagen-lysine,2-oxoglutarate 5-dioxygenase 2, TLH |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plod2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GT_LH
- procollagen-lysine 5-dioxygenase
- enzyme
- 2OG-Fe(II) oxygenase superfamily
- Prolyl 4-hydroxylase alpha subunit homologues
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatocellular carcinoma
- colorectal cancer
- metastatic colorectal cancer
- non-small cell lung cancer
- epithelial cancer
- Bruck syndrome 2
- metastasis
- Bruck syndrome
- organismal death
role in cell
- cell death
- invasion by
- migration
- proliferation
- tumorsphere formation by
- phosphorylation in
- degradation in
- deposition in
- replicative senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- rough endoplasmatic reticulum
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plod2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- hydroxylysine biosynthetic process
- response to hypoxia
- protein O-linked glycosylation
- peptidyl-lysine hydroxylation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- rough endoplasmic reticulum membrane
- extracellular vesicular exosome
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- L-ascorbic acid binding
- iron ion binding
- procollagen-lysine 5-dioxygenase activity
- procollagen glucosyltransferase activity