MAP4 Gene Summary [Human]
The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Details
| Type | Protein Coding |
| Official Symbol | MAP4 |
| Official Name | microtubule associated protein 4 [Source:HGNC Symbol;Acc:HGNC:6862] |
| Ensembl ID | ENSG00000047849 |
| Bio databases IDs | |
| Aliases | microtubule associated protein 4 |
| Synonyms | Microtubule Associated Protein 3, microtubule-associated protein 4, Mtap-4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAP4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- projection domain
- microtubule binding
- microtubule binding domain
- Family of unknown function (DUF5585)
- Tau and MAP protein, tubulin-binding repeat
- affinity domain
- tail domain
- protein binding
- structural molecule
- proline rich domain
- Serine Proline motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- myocardial infarction
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- metabolic syndrome X
- neonatal late-onset sepsis
- breast carcinoma
- COVID-19
- schizophrenia
- organismal death
role in cell
- cell death
- quantity
- phosphorylation in
- apoptosis
- migration
- disassembly
- binding
- invasion by
- replication in
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule aster fraction
- soluble fraction
- microtubule cytoskeleton
- cilia
- Plasma Membrane
- basal bodies
- microtubules
- axonemes
- microtubule organizing centers
- cytosol
- mitotic spindle
- axons
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAP4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- neuron projection development
- microtubule sliding
- mitotic spindle organization
- establishment of spindle orientation
- microtubule polymerization
- microtubule cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- mitotic spindle
- microtubule organizing center
- cytosol
- neuron projection
- plasma membrane
- axon
- microtubule associated complex
- axoneme
- microtubule
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- structural molecule activity
- microtubule binding