Mobp Gene Summary [Mouse]
A structural constituent of myelin sheath. Predicted to be involved in central nervous system myelin formation. Located in mitochondrion. Is expressed in central nervous system and eye. Human ortholog(s) of this gene implicated in frontotemporal dementia. Orthologous to human MOBP (myelin associated oligodendrocyte basic protein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mobp |
| Official Name | myelin-associated oligodendrocytic basic protein [Source:MGI Symbol;Acc:MGI:108511] |
| Ensembl ID | ENSMUSG00000032517 |
| Bio databases IDs | |
| Aliases | myelin-associated oligodendrocytic basic protein |
| Synonyms | LOC285281, MOBP155, MOBP170, MOBP69, MOBP73, MOBP81, Mobp81p, myelin-associated oligodendrocyte basic protein, myelin-associated oligodendrocytic basic protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mobp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- structural constituent of myelin sheath
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- diabetic nephropathy
- sporadic amyotrophic lateral sclerosis
- progressive supranuclear palsy
- amyotrophic lateral sclerosis
- glioblastoma
- glioblastoma cancer
- corticobasal degeneration
- attention deficit hyperactivity disorder
- susceptibility to amyotrophic lateral sclerosis
regulates
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mobp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system myelin formation
- nervous system development
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of myelin sheath