RBM5 Gene Summary [Human]
This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | RBM5 |
| Official Name | RNA binding motif protein 5 [Source:HGNC Symbol;Acc:HGNC:9902] |
| Ensembl ID | ENSG00000003756 |
| Bio databases IDs | |
| Aliases | RNA binding motif protein 5 |
| Synonyms | D030069N10RIK, G15, H37, LUCA-15, RMB5, RNA binding motif protein 5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RBM5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- Zn-finger in Ran binding protein and others
- G-patch domain
- RNA recognition motif
- mRNA binding
- OCRE domain
- protein binding
- zinc finger domain
- DNA binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoporosis
- tumorigenesis
- Alzheimer disease
- cervical small cell carcinoma
- extrapulmonary small cell cancer
- epithelial uterine cancer
- cervical cancer
- paroxysmal nocturnal hemoglobinuria
- bone resorption disorder
- infection by HIV-1
role in cell
- expression in
- proliferation
- phosphorylation in
- apoptosis
- growth
- formation
- formation in
- G2/M phase
- migration
- alternative splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- cytosol
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RBM5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of alternative nuclear mRNA splicing, via spliceosome
- negative regulation of cell proliferation
- positive regulation of apoptotic process
- apoptotic process
- RNA processing
- spliceosomal complex assembly
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- spliceosomal complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA binding
- protein binding
- metal ion binding
- mRNA binding