Nckipsd Gene Summary [Mouse]
Predicted to enable Arp2/3 complex binding activity. Involved in positive regulation of neuron projection development. Predicted to be located in several cellular components, including glutamatergic synapse; nucleoplasm; and postsynapse. Predicted to be part of COP9 signalosome. Is expressed in central nervous system and retina. Orthologous to human NCKIPSD (NCK interacting protein with SH3 domain). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nckipsd |
| Official Name | NCK interacting protein with SH3 domain [Source:MGI Symbol;Acc:MGI:1931834] |
| Ensembl ID | ENSMUSG00000032598 |
| Bio databases IDs | |
| Aliases | NCK interacting protein with SH3 domain |
| Synonyms | AF3P21, DIP, DIP1, NCK interacting protein with SH3 domain, ORF1, SPIN90, VIP54, Wasbp, WASLBP, WISH |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nckipsd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- leucine rich domain
- central domain
- protein binding
- proline rich domain
- verproline homology domain
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- open-angle glaucoma
- anorexia nervosa
- complete testicular feminization syndrome
role in cell
- adhesion
- migration
- trafficking
- formation
- abnormal morphology
- polymerization
- development
- organization
- morphology
- tubulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- invadopodia
- cell periphery
- postsynaptic region
- Nucleus
- cytosol
- membrane ruffles
- nucleoplasm
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nckipsd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- positive regulation of neuron projection development
- endocytosis
Cellular Component
Where in the cell the gene product is active
- cytosol
- intermediate filament
- signalosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- SH3 domain binding
- cytoskeletal protein binding
- Arp2/3 complex binding