Ip6k2 Gene Summary [Mouse]
Enables inositol hexakisphosphate kinase activity. Involved in inositol phosphate biosynthetic process. Acts upstream of or within positive regulation of peptidyl-serine phosphorylation and protein stabilization. Located in nucleus. Is expressed in several structures, including alimentary system; heart; nervous system; respiratory system; and sensory organ. Orthologous to human IP6K2 (inositol hexakisphosphate kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ip6k2 |
| Official Name | inositol hexaphosphate kinase 2 [Source:MGI Symbol;Acc:MGI:1923750] |
| Ensembl ID | ENSMUSG00000032599 |
| Bio databases IDs | |
| Aliases | inositol hexaphosphate kinase 2 |
| Synonyms | 1500005N04RIK, AW050208, IHPK2, inositol hexakisphosphate kinase 2, inositol hexaphosphate kinase 2, InsP6K2, PIUS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ip6k2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- traf2 binding domain
- diphosphoinositol-pentakisphosphate kinase
- binding protein
- phosphate group acceptor phosphotransferase
- inositol-hexakisphosphate kinase
- alcohol group acceptor phosphotransferase
- Inositol polyphosphate kinase
- protein binding
- inositol phosphate binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- neoplasia
- metastasis
- hypertension
- Huntington disease
- inflammatory bowel disease
- insomnia
- Parkinson disease
- hyperplasia
role in cell
- adhesion
- migration
- apoptosis
- proliferation
- phosphorylation in
- cell death
- growth
- colony formation
- function
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- cell junction
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ip6k2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inositol phosphate biosynthetic process
- inositol phosphate metabolic process
- negative regulation of cell growth
- positive regulation of apoptotic process
- phosphatidylinositol phosphorylation
- protein stabilization
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cell junction
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- flavonoid binding
- ATP binding
- inositol heptakisphosphate kinase activity
- protein binding
- inositol hexakisphosphate kinase activity
- inositol-1,3,4,5,6-pentakisphosphate kinase activity
- inositol diphosphate tetrakisphosphate kinase activity
- inositol 5-diphosphate pentakisphosphate 5-kinase activity
- inositol hexakisphosphate 5-kinase activity