Abtb2 Gene Summary [Mouse]
Predicted to enable protein heterodimerization activity. Acts upstream of or within cellular response to toxic substance. Is expressed in several structures, including central nervous system; hindlimb long bone; limb segment; respiratory system cartilage; and sensory organ. Orthologous to human ABTB2 (ankyrin repeat and BTB domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abtb2 |
| Official Name | ankyrin repeat and BTB (POZ) domain containing 2 [Source:MGI Symbol;Acc:MGI:2139365] |
| Ensembl ID | ENSMUSG00000032724 |
| Bio databases IDs | |
| Aliases | ankyrin repeat and BTB (POZ) domain containing 2 |
| Synonyms | ABTB2A, ankyrin repeat and BTB domain containing 2, AW539457, BTBD22, CCA3, DKFZp586C1619 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Abtb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone fold domain (HFD) superfamily
- Ankyrin repeats (many copies)
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- Ankyrin repeats (3 copies)
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Abtb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to toxin
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein heterodimerization activity