Ank2 Gene Summary [Mouse]
Enables several functions, including ATPase binding activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in several processes, including positive regulation of ion transmembrane transporter activity; regulation of cardiac muscle cell action potential; and regulation of heart contraction. Acts upstream of or within cardiac muscle contraction; regulation of cardiac muscle cell membrane potential; and regulation of cation channel activity. Located in several cellular components, including T-tubule; intercalated disc; and myofibril. Is active in paranodal junction. Is extrinsic component of cytoplasmic side of plasma membrane. Is expressed in central nervous system; eye; genitourinary system; and heart. Used to study ankyrin-B-related cardiac arrhythmia; autistic disorder; and sinoatrial node disease. Human ortholog(s) of this gene implicated in ankyrin-B-related cardiac arrhythmia; atrial fibrillation; long QT syndrome; and sick sinus syndrome. Orthologous to human ANK2 (ankyrin 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ank2 |
| Official Name | ankyrin 2, brain [Source:MGI Symbol;Acc:MGI:88025] |
| Ensembl ID | ENSMUSG00000032826 |
| Bio databases IDs | |
| Aliases | ankyrin 2, brain |
| Synonyms | Ank3, AnkB, ankyrin, ankyrin 2, ankyrin 2, brain, ANKYRIN-B, Brain ankyrin, brank-2, BX537758, CFAP87, FAP87, Gm4392, LOC103691695, LQT4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ank2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- Ankyrin repeats (many copies)
- channel regulator
- protein kinase binding
- regulatory domain
- membrane-association domain
- potassium channel regulator
- protein binding activity, bridging
- enzyme binding
- Ankyrin repeats (3 copies)
- spectrin binding
- protein binding
- zDHHC ankyrin repeat binding domain
- UPA domain
- ZU5 domain
- Ankyrin repeat
- ATPase binding
- structural constituent of cytoskeleton
- spectrin binding domain
- ion channel binding
- Metaviral_G glycoprotein
- Death Domain Superfamily of protein-protein interaction domains
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cervical cancer
- heart failure
- long QT4 syndrome
- non-insulin-dependent diabetes mellitus
- developmental disorder
- cardiac arrhythmia ankyrin-b related
- ventricular arrhythmia
- preeclampsia
- catecholaminergic polymorphic ventricular tachycardia type 1
- acute myeloid leukemia
role in cell
- expression in
- proliferation
- quantity
- binding in
- accumulation in
- binding
- organization
- contraction
- density
- pruning
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-soluble membrane fractions
- Cytoplasm
- perinuclear region
- cellular membrane
- costameres
- intercellular junctions
- sarcomere
- cytosol
- cytoplasmic face of plasma membrane
- basolateral membrane
- growth cone
- paranodes
- paranodal junctions
- axon initial segments
- m-bands
- A bands
- sarcolemma
- Z line
- transverse tubules
- perikaryon
- axons
- postsynaptic density
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ank2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization at cell surface
- regulation of atrial cardiac muscle cell action potential
- cytoskeleton organization
- regulation of SA node cardiac muscle cell action potential
- protein transport
- positive regulation of calcium ion transport
- protein localization
- regulation of ventricular cardiomyocyte membrane repolarization
- positive regulation of potassium ion transport
- regulation of calcium ion transport
- membrane depolarization involved in regulation of SA node cardiac muscle cell action potential
- T-tubule organization
- atrial cardiomyocyte to AV node cell communication
- regulation of cardiac muscle cell contraction
- regulation of ventricular cardiac muscle cell action potential
- atrial septum development
- endocytosis
- cellular calcium ion homeostasis
- regulation of release of sequestered calcium ion into cytosol
- regulation of heart rate
- response to methylmercury
- regulation of protein stability
- paranodal junction assembly
- sarcoplasmic reticulum calcium ion transport
- positive regulation of gene expression
- positive regulation of cation channel activity
- regulation of heart rate by cardiac conduction
- protein localization to organelle
- SA node cardiomyocyte to atrial cardiomyocyte communication
- protein localization in endoplasmic reticulum
- regulation of cardiac muscle contraction by calcium ion signaling
- protein stabilization
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
- regulation of cardiac muscle contraction
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- costamere
- neuron projection
- plasma membrane
- lysosome
- T-tubule
- Z disc
- early endosome
- cytoskeleton
- postsynaptic membrane
- sarcolemma
- mitochondrion
- cytosol
- intercalated disc
- recycling endosome
- M band
- A band
- basolateral plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- cytoskeletal adaptor activity
- protein binding
- spectrin binding
- structural constituent of cytoskeleton
- protein binding, bridging
- ion channel binding
- enzyme binding
- ATPase binding