Chl1 Gene Summary [Mouse]
Enables protease binding activity. Involved in negative regulation of neuron apoptotic process. Acts upstream of or within several processes, including adult locomotory behavior; exploration behavior; and generation of neurons. Located in apical part of cell and dendrite. Is expressed in head mesenchyme; nervous system; and retina. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human CHL1 (cell adhesion molecule L1 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chl1 |
| Official Name | cell adhesion molecule L1-like [Source:MGI Symbol;Acc:MGI:1098266] |
| Ensembl ID | ENSMUSG00000030077 |
| Bio databases IDs | |
| Aliases | cell adhesion molecule L1-like |
| Synonyms | A530023M13Rik, AI465420, CALL, cell adhesion molecule L1-like, L1CAM2, LICAM2, LOC108350698 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protease binding
- immunoglobulin domain
- ectodomain
- Immunoglobulin I-set domain
- protein binding
- Fibronectin type 3 domain
- T-cell surface glycoprotein CD3 delta chain
- integrin binding domain
- FIGAY motif
- FN3
- Immunoglobulin like
- Bravo-like intracellular region
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometriosis
- COVID-19
- Alzheimer disease
- malignant peripheral nerve sheath tumor
- cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- Parkinson disease
- sudden cardiac arrest
- digestive system disorder
role in cell
- migration
- apoptosis
- cell death
- quantity
- density
- differentiation
- development
- accumulation
- accumulation in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- apical compartment
- cellular membrane
- growth cone
- synaptosomes
- perikaryon
- dendrites
- axon terminals
- mossy fibers
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- exploration behavior
- neuron migration
- cognition
- signal transduction
- axon guidance
- cell adhesion
- adult locomotory behavior
- negative regulation of neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- dendrite
- extracellular vesicular exosome
- apical part of cell
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protease binding