Pwp2 Gene Summary [Mouse]
Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and ribosomal small subunit assembly. Predicted to be located in nucleolus. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human PWP2 (PWP2 small subunit processome component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pwp2 |
| Official Name | PWP2 periodic tryptophan protein homolog (yeast) [Source:MGI Symbol;Acc:MGI:1341200] |
| Ensembl ID | ENSMUSG00000032834 |
| Bio databases IDs | |
| Aliases | PWP2 periodic tryptophan protein homolog (yeast) |
| Synonyms | 6530411D08Rik, EHOC-17, LOC687601, PWP2H, PWP2 periodic tryptophan protein homolog (yeast), PWP2 small subunit processome component, PWP2, small subunit processome component, UTP1, wdp103 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pwp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
- Dip2/Utp12 Family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pre-ribosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pwp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- ribosomal small subunit biogenesis
- ribosomal small subunit assembly
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- Pwp2p-containing subcomplex of 90S preribosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding