Exosc5 Gene Summary [Mouse]
Predicted to enable RNA binding activity. Acts upstream of or within RNA catabolic process. Predicted to be located in cytosol; euchromatin; and nucleoplasm. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Predicted to be active in nucleolus. Is expressed in several structures, including cerebral cortex; early conceptus; gonad; liver; and muscle tissue. Orthologous to human EXOSC5 (exosome component 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Exosc5 |
| Official Name | exosome component 5 [Source:MGI Symbol;Acc:MGI:107889] |
| Ensembl ID | ENSMUSG00000061286 |
| Bio databases IDs | |
| Aliases | exosome component 5 |
| Synonyms | CABAC, CML28, D7Wsu180e, Exosome component 5, hRrp46p, p12B, RRP41B, RRP46, Rrp46p |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Exosc5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3' exoribonuclease family, domain 2
- RNase PH-like 3'-5' exoribonucleases
- enzyme
- protein binding
- 3' exoribonuclease family, domain 1
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cerebellar ataxia, brain abnormalities and cardiac conduction defects
- organismal death
- infection by HIV-1
role in cell
- expression in
- sphere formation
- tumorigenicity
- replication in
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
- chromatin
- exosomes
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Exosc5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- polyadenylation-dependent snoRNA 3'-end processing
- U4 snRNA 3'-end processing
- rRNA catabolic process
- nuclear-transcribed mRNA catabolic process
- nuclear mRNA surveillance
- defense response to virus
- DNA deamination
- RNA processing
- rRNA processing
- mRNA catabolic process
- RNA catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasmic exosome (RNase complex)
- nucleus
- nuclear exosome (RNase complex)
- euchromatin
- cytoplasm
- cytosol
- nucleolus
- nucleoplasm
- exosome (RNase complex)
Molecular Function
What the gene product does at the molecular level
- DNA binding
- 3'-5'-exoribonuclease activity
- RNA binding
- protein binding
- exoribonuclease activity