Usf2 Gene Summary [Mouse]
Enables DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in glucose mediated signaling pathway; lipid homeostasis; and positive regulation of transcription from RNA polymerase II promoter by glucose. Acts upstream of or within lactation; positive regulation of DNA-templated transcription; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; genitourinary system; and sensory organ. Orthologous to human USF2 (upstream transcription factor 2, c-fos interacting). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usf2 |
| Official Name | upstream transcription factor 2 [Source:MGI Symbol;Acc:MGI:99961] |
| Ensembl ID | ENSMUSG00000058239 |
| Bio databases IDs | |
| Aliases | upstream transcription factor 2 |
| Synonyms | bHLHb12, FIP, upstream transcription factor 2, upstream transcription factor 2, c-fos interacting |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Usf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription activation domain
- transcription factor binding
- USF-specific region
- identical protein binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- basic helix-loop-helix-leucine zipper domain
- Helix-loop-helix DNA-binding domain
- basic domain
- bZIP
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- dimerization domain
- DNA binding domain
- nucleic acid binding
- basic Helix Loop Helix (bHLH) domain superfamily
- coiled-coil domain found in the geminin family
- protein binding
- sequence-specific DNA binding
- DNA binding
- binding protein
- double-stranded DNA binding
- helix loop helix domain
- protein homodimerization
- transcription factor activity
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- endometriosis
- hyperplasia
- prostate cancer
- cholesteatoma
- seizures
- side effect
role in cell
- growth
- expression in
- colony formation
- tumorigenicity
- transformation
- invasion by
- response by
- transcription in
- activation in
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- nucleoplasm
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Usf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter by glucose
- late viral mRNA transcription
- lipid homeostasis
- lactation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter by glucose
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein homodimerization activity
- protein binding
- protein heterodimerization activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- bHLH transcription factor binding