Pygb Gene Summary [Mouse]
Enables glycogen phosphorylase activity. Involved in glycogen catabolic process. Predicted to be located in axon. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; nervous system; sensory organ; and urinary system. Orthologous to human PYGB (glycogen phosphorylase B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pygb |
| Official Name | brain glycogen phosphorylase [Source:MGI Symbol;Acc:MGI:97828] |
| Ensembl ID | ENSMUSG00000033059 |
| Bio databases IDs | |
| Aliases | brain glycogen phosphorylase |
| Synonyms | brain glycogen phosphorylase, glycogen phosphorylase B, GLYPHOA, GPBB, KW9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pygb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycosyltransferase family 1 and related proteins with GTB topology
- Carbohydrate phosphorylase
- glycogen/starch/alpha-glucan phosphorylases
- enzyme
- protein binding
- carbohydrate binding
- identical protein binding
- phosphorylase
- glycogen phosphorylase
Pathways
Biological processes and signaling networks where the Pygb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by Influenza A virus subtype H1N1
- epithelial cancer
- organismal death
- hepatocellular carcinoma
- liver cancer
- peripheral arterial disease
regulates
- glycogen
role in cell
- selumetinib sensitivity
- trametinib sensitivity
- dasatinib sensitivity
- mirdametinib sensitivity
- SCH772984 sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- extracellular vesicles
- azurophil granule lumen
- Extracellular Space
- cellular membrane
- axons
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pygb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycogen catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- membrane
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- glycogen phosphorylase activity
- pyridoxal phosphate binding
- protein binding