Arf1 Gene Summary [Mouse]
Enables GTP binding activity and magnesium ion binding activity. Involved in mitotic cleavage furrow ingression. Acts upstream of or within vesicle-mediated transport. Located in Golgi apparatus; cytosol; and sarcomere. Part of protein-containing complex. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system; and integumental system. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARF1 (ARF GTPase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arf1 |
| Official Name | ADP-ribosylation factor 1 [Source:MGI Symbol;Acc:MGI:99431] |
| Ensembl ID | ENSMUSG00000048076 |
| Bio databases IDs | |
| Aliases | ADP-ribosylation factor 1 |
| Synonyms | ARF GTPase 1, PVNH8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding domain-switch II region
- GTPase
- protein domain specific binding
- enzyme
- protein binding
- magnesium ion binding
- GTP binding domain-switch I domain
- phospholipase activator
- effector domain
- GTP binding
- ADP-ribosylation factor family
- GTPase domain
- GDP binding
- myristoylation sequence
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- guanine nucleotide exchange factor domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- myristoylation signal domain
Pathways
Biological processes and signaling networks where the Arf1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- periventricular nodular heterotopia type 8
- endometriosis
- rheumatoid arthritis
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
role in cell
- expression in
- apoptosis
- shedding in
- growth
- maturation
- phosphorylation in
- cell viability
- activation in
- migration
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- glutaminergic synapse
- endomembrane system
- perinuclear region
- microvesicles
- membrane surface
- Plasma Membrane
- Golgi Apparatus
- sarcomere
- cytosol
- endoplasmic reticulum exit sites
- Golgi membrane
- trans Golgi network
- peroxisome membrane
- perinucleolar compartments
- late endosomes
- cell membrane leading edge
- postsynaptic density
- exosomes
- clathrin-coated vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- regulation of receptor internalization
- cellular copper ion homeostasis
- dendritic spine organization
- long term synaptic depression
- intracellular protein transport
- regulation of Arp2/3 complex-mediated actin nucleation
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- extracellular vesicular exosome
- focal adhesion
- cell leading edge
- cytoplasm
- cytosol
- Golgi membrane
- macromolecular complex
- neuron projection
- sarcomere
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- GTP binding
- protein domain specific binding
- protein binding
- RNA binding
- GTPase activity