Myh2 Gene Summary [Mouse]
Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within response to muscle activity. Located in A band; actomyosin contractile ring; and cell-cell junction. Is expressed in several structures, including alimentary system; forelimb bud mesenchyme; and skeletal musculature. Human ortholog(s) of this gene implicated in congenital myopathy 6 and inclusion body myositis. Orthologous to human MYH2 (myosin heavy chain 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Myh2 |
| Official Name | myosin, heavy polypeptide 2, skeletal muscle, adult [Source:MGI Symbol;Acc:MGI:1339710] |
| Ensembl ID | ENSMUSG00000033196 |
| Bio databases IDs | |
| Aliases | myosin, heavy polypeptide 2, skeletal muscle, adult |
| Synonyms | CMYO6, CMYP6, IBM3, MHC2A, MHC-IIa, MHC type2 FAST, Myh1, MYH2A, MYHas8, Myhc2, MyHC-2A, Myhcf, MyHC-IIA, MYHSA2, Myhs-f, Myhs-f1, myosin heavy chain 2, Myosin heavy chain type iia, myosin, heavy polypeptide 2, skeletal muscle, adult, MYPOP, sMHC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myh2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Synaptonemal complex protein 1 (SCP-1)
- microfilament motor protein
- Myosin N-terminal SH3-like domain
- helix-rich Mycoplasma protein
- enzyme
- Laminin Domain I
- chromosome segregation protein SMC, common bacterial type
- HOOK protein coiled-coil region
- Mitotic checkpoint protein
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- Weak chloroplast movement under blue light
- Myosin and Kinesin motor domain
- rad50
- Myosin tail
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Myosin head (motor domain)
- Alpha helical coiled-coil rod protein (HCR)
- RecF/RecN/SMC N terminal domain
- RIM-binding protein of the cytomatrix active zone
- Intermediate filament protein
- Apolipoprotein A1/A4/E domain
- Septation ring formation regulator, EzrA
- Myosin
Pathways
Biological processes and signaling networks where the Myh2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Agranulocyte Adhesion and Diapedesis
- Calcium Signaling
- Cellular Effects of Sildenafil (Viagra)
- Epithelial Adherens Junction Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- ILK Signaling
- Phagosome Formation
- Protein Kinase A Signaling
- RhoGDI Signaling
- Tight Junction Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- proximal myopathy and ophthalmoplegia
- autosomal dominant myopathy
- squamous-cell carcinoma
- autosomal recessive congenital myopathy type 6 with ophthalmoplegia
- papilloma
- papillomatosis
- squamous cell cancer
- myopathy
- oral submucous fibrosis
- autosomal dominant congenital myopathy type 6 with ophthalmoplegia
regulates
role in cell
- morphology
- assembly
- repair
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Plasma Membrane
- Golgi Apparatus
- contractile rings
- myofilaments
- intercellular junctions
- sarcomere
- cytosol
- myofibrils
- actin stress fibers
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myh2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle contraction
- muscle filament sliding
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- muscle myosin complex
- cytoplasm
- myosin II complex
- myosin filament
- cytosol
- macromolecular complex
- sarcomere
- myofibril
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- ATP binding
- calmodulin binding
- protein binding
- microfilament motor activity