Ttc28 Gene Summary [Mouse]
Predicted to enable kinase binding activity. Predicted to be involved in regulation of mitotic cell cycle. Predicted to be located in microtubule cytoskeleton and midbody. Is expressed in several structures, including central nervous system; genitourinary system; heart; and retina. Orthologous to human TTC28 (tetratricopeptide repeat domain 28). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ttc28 |
| Official Name | tetratricopeptide repeat domain 28 [Source:MGI Symbol;Acc:MGI:2140873] |
| Ensembl ID | ENSMUSG00000033209 |
| Bio databases IDs | |
| Aliases | tetratricopeptide repeat domain 28 |
| Synonyms | 2310015L07RIK, 6030435N04, AK122427 (KIAA gene family), KIAA1043, tetratricopeptide repeat domain 28, TPRBK |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ttc28 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MalT-like TPR region
- TPR repeat
- kinase binding
- Tetratricopeptide repeats
- mitochondrial import receptor subunit TOM70
- putative PEP-CTERM system TPR-repeat lipoprotein
- tetratricopeptide repeat
- CHAT domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- midbody
- spindle pole
- central spindle
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ttc28 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasm
- spindle pole
- midbody
Molecular Function
What the gene product does at the molecular level
- kinase binding