Eri3 Gene Summary [Mouse]
Predicted to enable 3'-5'-RNA exonuclease activity; metal ion binding activity; and nucleic acid binding activity. Predicted to be located in plasma membrane. Is expressed in several structures, including brain; eye; genitourinary system; major salivary gland; and trigeminal nerve. Orthologous to human ERI3 (ERI1 exoribonuclease family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eri3 |
| Official Name | exoribonuclease 3 [Source:MGI Symbol;Acc:MGI:2153887] |
| Ensembl ID | ENSMUSG00000033423 |
| Bio databases IDs | |
| Aliases | exoribonuclease 3 |
| Synonyms | ERI1 exoribonuclease family member 3, exoribonuclease 3, LOC100361570, PINT1, PRNPIP, Prnpip1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eri3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
- exonuclease
- EXOIII
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eri3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Molecular Function
What the gene product does at the molecular level
- 3'-5'-exoribonuclease activity
- RNA binding
- metal ion binding