Catsper2 Gene Summary [Mouse]
Enables voltage-gated calcium channel activity. Involved in calcium ion transport. Acts upstream of or within fertilization; flagellated sperm motility; and sperm capacitation. Located in sperm flagellum. Part of CatSper complex. Orthologous to human CATSPER2 (cation channel sperm associated 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Catsper2 |
| Official Name | cation channel, sperm associated 2 [Source:MGI Symbol;Acc:MGI:2387404] |
| Ensembl ID | ENSMUSG00000033486 |
| Bio databases IDs | |
| Aliases | cation channel, sperm associated 2 |
| Synonyms | cation channel sperm associated 2, cation channel, sperm associated 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Catsper2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- voltage-gated calcium channel
- Ion transport protein
- protein binding
- ion channel
Pathways
Biological processes and signaling networks where the Catsper2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Androgen Signaling
- Calcium Signaling
- CCR5 Signaling in Macrophages
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- CREB Signaling in Neurons
- FcγRIIB Signaling in B Lymphocytes
- G Beta Gamma Signaling
- GABA Receptor Signaling
- GNRH Signaling
- GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells
- Gustation Pathway
- Mitochondrial Dysfunction
- Netrin Signaling
- nNOS Signaling in Skeletal Muscle Cells
- Opioid Signaling Pathway
- PKCθ Signaling in T Lymphocytes
- Role of NFAT in Cardiac Hypertrophy
- Sperm Motility
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- flagella
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Catsper2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm motility
- sperm capacitation
- calcium ion transport
- calcium ion transmembrane transport
- fertilization
Cellular Component
Where in the cell the gene product is active
- motile cilium
- plasma membrane
- CatSper complex
Molecular Function
What the gene product does at the molecular level
- calcium activated cation channel activity
- protein binding
- voltage-gated calcium channel activity