Cacna1i Gene Summary [Mouse]
Predicted to enable low voltage-gated calcium channel activity and voltage-gated sodium channel activity. Acts upstream of or within neuronal action potential and sleep. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in neuron projection. Is expressed in brain. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human CACNA1I (calcium voltage-gated channel subunit alpha1 I). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cacna1i |
| Official Name | calcium channel, voltage-dependent, alpha 1I subunit [Source:MGI Symbol;Acc:MGI:2178051] |
| Ensembl ID | ENSMUSG00000022416 |
| Bio databases IDs | |
| Aliases | calcium channel, voltage-dependent, alpha 1I subunit |
| Synonyms | alpha1I, Calcium Channel alpha1i, calcium channel, voltage-dependent, alpha 1I subunit, calcium channel, voltage-dependent, α 1I subunit, calcium voltage-gated channel subunit alpha1 I, Ca(V)3.3, CAV3.3, NEDSIS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cacna1i often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- voltage-gated calcium channel
- Ion transport protein
- low voltage-gated calcium channel
- protein binding
- ion channel
- Polycystin cation channel
Pathways
Biological processes and signaling networks where the Cacna1i gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Androgen Signaling
- Calcium Signaling
- CCR5 Signaling in Macrophages
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- CREB Signaling in Neurons
- FcγRIIB Signaling in B Lymphocytes
- G Beta Gamma Signaling
- GABA Receptor Signaling
- GNRH Signaling
- GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells
- Gustation Pathway
- Mitochondrial Dysfunction
- Netrin Signaling
- nNOS Signaling in Skeletal Muscle Cells
- Opioid Signaling Pathway
- PKCθ Signaling in T Lymphocytes
- Role of NFAT in Cardiac Hypertrophy
- Serotonin Receptor Signaling
- Sperm Motility
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- metabolic syndrome X
- obesity
- weight gain
- prostate cancer
- major depression
- juvenile rheumatoid arthritis
- bipolar disorder
- schizophrenia
- migraines
regulates
- Ca2+
role in cell
- transmembrane potential
- action potential
- transport in
- synaptic plasticity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cacna1i gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- sleep
- regulation of action potential in neuron
Cellular Component
Where in the cell the gene product is active
- voltage-gated calcium channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- high voltage-gated calcium channel activity
- voltage-gated calcium channel activity