Cbx7 Gene Summary [Mouse]
Enables chromatin binding activity; histone H3K9me2/3 reader activity; and single-stranded RNA binding activity. Acts upstream of or within sebaceous gland development. Located in heterochromatin and nucleus. Part of PRC1 complex. Is expressed in brain. Human ortholog(s) of this gene implicated in breast cancer; multiple myeloma; and myeloid leukemia. Orthologous to human CBX7 (chromobox 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cbx7 |
| Official Name | chromobox 7 [Source:MGI Symbol;Acc:MGI:1196439] |
| Ensembl ID | ENSMUSG00000053411 |
| Bio databases IDs | |
| Aliases | chromobox 7 |
| Synonyms | 1600014J01Rik, chromobox 7, D15ERTD417E |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cbx7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Chromatin organization modifier domain
- CBX family C-terminal motif
- CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
- protein binding activity, bridging
- chromatin binding
- protein binding
- single-stranded RNA binding
- Chromo (CHRromatin organization MOdifier) domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- organismal death
- lung carcinoma process
- epithelial cancer
- lung cancer
- epithelial neoplasia
- thoracic cancer
- endometrial cancer
- liver cancer
role in cell
- proliferation
- growth
- expression in
- migration
- acetylation in
- cell cycle progression
- sphere formation
- tumorigenicity
- colony formation
- inactivation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- cytosol
- nuclear foci
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cbx7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- PRC1 complex
- PcG protein complex
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding