Tuba1c Gene Summary [Mouse]
Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Located in cytoplasmic microtubule. Is expressed in cerebral cortex. Orthologous to human TUBA1C (tubulin alpha 1c). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tuba1c |
| Official Name | tubulin, alpha 1C [Source:MGI Symbol;Acc:MGI:1095409] |
| Ensembl ID | ENSMUSG00000043091 |
| Bio databases IDs | |
| Aliases | tubulin, alpha 1C |
| Synonyms | alpha 6 TUBULIN, bcm948, LOC100862648, LOC100909441, LOC102723916, M[a]6, Tuba1, TUBA6, tubulin alpha 1c, tubulin, alpha 1C, Tubulin alpha 6, tubulin α 1c, tubulin, α 1C, Tubulin α 6, α 6 TUBULIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tuba1c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tubulin protein family of FtsZ and CetZ-like
- Tubulin C-terminal domain
- Tubulin/FtsZ family, GTPase domain
- protein binding
- Tubulin/FtsZ family, C-terminal domain
- structural molecule
- phosphorylation site
Pathways
Biological processes and signaling networks where the Tuba1c gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- non-small cell lung cancer
- non-small cell lung carcinoma
- non-squamous non-small cell lung cancer
- lung squamous cell carcinoma
- infection
- classical Hodgkin lymphoma
- mixed cellularity classical Hodgkin lymphoma
- cancer
- lymphoma
regulates
- alpha tubulin
role in cell
- phosphorylation in
- motility
- cell division
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- cilia
- Nucleus
- microtubules
- nucleoli
- synaptic vesicles
- growth cone
- cytoplasmic microtubule
- membrane rafts
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tuba1c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- cytoskeleton-dependent intracellular transport
- microtubule cytoskeleton organization
- mitotic cell cycle
- microtubule-based process
Cellular Component
Where in the cell the gene product is active
- nucleus
- microtubule cytoskeleton
- cytoplasm
- membrane raft
- vesicle
- cytoplasmic microtubule
- microtubule
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- metal ion binding
- structural molecule activity
- structural constituent of cytoskeleton
- hydrolase activity