Pla2g4c Gene Summary [Mouse]

Predicted to enable several functions, including calcium ion binding activity; calcium-dependent phospholipid binding activity; and phospholipase activity. Predicted to be involved in glycerophospholipid metabolic process and lipid droplet formation. Located in cell cortex; nuclear envelope; and nucleoplasm. Is expressed in central nervous system; early conceptus; ovary; and retina. Orthologous to human PLA2G4C (phospholipase A2 group IVC). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Pla2g4c
Official Name
phospholipase A2, group IVC (cytosolic, calcium-independent) [Source:MGI Symbol;Acc:MGI:1196403]
Ensembl ID
ENSMUSG00000033847
Bio databases IDs NCBI: 232889 Ensembl: ENSMUSG00000033847
Aliases phospholipase A2, group IVC (cytosolic, calcium-independent)
Synonyms CPLA2-gamma, CPLA2-γ, D7Ertd445e, phospholipase A2 group IVC, phospholipase A2, group IVC (cytosolic, calcium-independent), Pla2g4cl1, Pla2g4cl2
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pla2g4c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Patatins and Phospholipases
  • Cytoplasmic phospholipase A2, catalytic subunit
  • lysophospholipase
  • phospholipase A1
  • calcium-independent phospholipase A2
  • enzyme
  • protein binding
  • prenylation site
  • O-acyltransferase
  • phospholipase A2

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • systemic lupus erythematosus
  • androgenic alopecia
  • pemphigus foliaceus
  • amyotrophic lateral sclerosis
regulated by
regulates
  • phospholipid
  • arachidonic acid
  • platelet activating factor
  • palmitic acid
  • phosphatidylcholine
  • fatty acid
  • oleic acid
  • stearic acid
  • glycerophospholipid
role in cell
  • formation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane
  • cell cortex
  • Golgi Apparatus
  • Endoplasmic Reticulum
  • Mitochondria
  • lipid droplets
  • cytosol
  • endoplasmic reticulum membrane
  • mitochondrial membrane
  • nucleoplasm
  • nuclear envelope

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Pla2g4c gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • inflammatory response
  • phosphatidylcholine acyl-chain remodeling
  • glycerophospholipid catabolic process
  • phosphatidylethanolamine acyl-chain remodeling
  • platelet activating factor biosynthetic process
  • phospholipid metabolic process
  • arachidonic acid metabolic process
  • intracellular signal transduction
  • parturition

Cellular Component

Where in the cell the gene product is active
  • lipid particle
  • nuclear envelope
  • endoplasmic reticulum membrane
  • mitochondrial membrane
  • cell cortex
  • membrane
  • cytosol
  • plasma membrane
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • lysophospholipase activity
  • protein binding
  • calcium-independent phospholipase A2 activity
  • calcium-dependent phospholipase A2 activity
  • O-acyltransferase activity
  • calcium ion binding
  • phosphatidylcholine 1-acylhydrolase activity
  • phospholipid binding
  • calcium-dependent phospholipid binding

Gene-Specific Assays for Results You Can Trust

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