Cpsf1 Gene Summary [Mouse]

Predicted to enable enzyme binding activity and mRNA 3'-UTR AU-rich region binding activity. Predicted to be involved in mRNA processing. Predicted to be located in nucleoplasm. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Predicted to be active in nucleus. Is expressed in central nervous system; sensory organ; thymus; and tooth. Human ortholog(s) of this gene implicated in myopia. Orthologous to human CPSF1 (cleavage and polyadenylation specific factor 1). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Retained Intron
Official Symbol
Cpsf1
Official Name
cleavage and polyadenylation specific factor 1 [Source:MGI Symbol;Acc:MGI:2679722]
Ensembl ID
ENSMUSG00000034022
Bio databases IDs NCBI: 94230 Ensembl: ENSMUSG00000034022
Aliases cleavage and polyadenylation specific factor 1
Synonyms cleavage and polyadenylation specific factor 1, CPSF160, Cpsf 160 kDa Subunit, HSU37012, MYP27, P/cl.18
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cpsf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • mRNA 3' UTR binding
  • Mono-functional DNA-alkylating methyl methanesulfonate N-term
  • enzyme binding
  • protein binding
  • CPSF A subunit region

Pathways

Biological processes and signaling networks where the Cpsf1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • autosomal dominant myopia type 27
regulated by
regulates
role in cell
  • degradation in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nucleoplasm
  • interchromatin granule clusters
  • plasma

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Cpsf1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • mRNA processing

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • mRNA cleavage and polyadenylation specificity factor complex
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • mRNA 3'-UTR AU-rich region binding
  • enzyme binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.